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The CRISPR-Cas9 system has fundamentally changed the way scientists can edit genes. From turning gene expression on and off to fluorescently tagging of particular sequences, this animation explores some of the exciting possibilities of CRISPR. For more information go to: http://www.nature.com/nmeth/focus/crisprtoolbox/index.html Produced with support from Dharmacon: www.dharmacon.com Nature has full responsibility for all editorial content, including Nature Video content. This content is editorially independent of sponsors.